早坂 晴子

略歴

大阪大学理学部(生物学科)卒業
大阪大学微生物病研究所腫瘍ウイルス部門(平成2年~6年)
薬理学医科学修士修了
大阪大学薬理学臓器制御部門(平成6年~9年)
医学研究科博士課程修了
東京都臨床医学総合研究所 細胞生物部門
CREST研究員 (平成9年~11年)
米国バージニア大学研究員 J. Tom Parsons 研究室(平成11年~16年)

家族:夫、長男(14歳)、次男(12歳)
家庭での研究課題:1、どうやって男の子二人をおとなしくさせるか 

研究テーマ

現在の興味・研究対象はリンパ節の発生です。現在までリンパ球の発生に関しては多くの研究がなされてきましたが、そのリンパ球の働く場であるリンパ節がどのようにできてくるか関してはほとんど未知の状態です。免疫学の教科書にも発生の教科書にも明確な記述はありません。リンパ節原基の誘導は発生の比較的後期に胎肝細胞由来の細胞と中胚葉系の細胞との相互作用により始まると考えられています。その後中胚葉細胞はストローマ細胞、濾胞樹状細胞、高内皮細静脈(HEV)に分化し、リンパ球が移入できるような構造をととのえます。私たちのグループでは、HEVの分化を誘導する分子メカニズムの解明を目標にしています。発生期のリンパ節からHEVを精製し解析すること、また未成熟な中胚葉細胞をES細胞(胚性幹細胞)から誘導し、さらにHEVの特性を持つ細胞に分化させることを試みています。

業績

1.Umemoto, E., Takeda, A., Jin, S., Luo, Z., Nakahogi, N., Hayasaka, H., Lee, CM., Tanaka, T., and Miyasaka, M. Dynamic changes in endothelial cell adhesion molecule nepmucin/CD300LG expression under physiological and pathological conditions. PLoS ONE, In press.

2.Ding, Q., Cai, G-Q., Hu, M., Yang, Y., Zheng, A., Tang, Q., Gladson, CL., Hayasaka, H., Wu, H., You, Z., Southern, BD., Grove, LM., Rahaman, SO., Fang,H., and Olman, MA. FAK-related nonkinase is a multifunctional negative regulator of pulmonary fibrosis. (2013) Am. J. Pathol., 182: 1572-1584.

3. Bai, Z., Cai, L., Umemoto, E., Takeda, A., Tohya, K., Komai, Y., Veeraveedu, PT., Hata, E., Sugiura, Y., Kubo, A., Suematsu, M., Hayasaka, H., Okudaira, S., Aoki, J., Tanaka T., Albers, HMHG., Ovaa, H., and Miyasaka, M. Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by the autotaxin/lysophosphatidic acid axis. (2013) J. Immunol., 190: 2036-2048.

4. Umemoto, E., Otani, K Ikeno, T., Verjan Garcia N, Hayasaka, H., Bai, Z., Jang MH., Tanaka T., Ueda, K., and Miyasaka, M. Constitutive plasmacytoid dendritic cell migration to the splenic white pulp is cooperatively regulated by CCR7- and CXCR4-mediated signaling. (2012)
J. Immunol., 189: 191-199.

5. Ogino, S., Nishida, N., Umemoto, R., Suzuki, M., Takeda, M., Terasawa, H., Kitayama, J., Matsumoto, M., Hayasaka, H., Miyasaka, M., and Shimada, I. Two-state conformations in the hyaluronan-binding domain regulate CD44 adhesiveness under flow condition. (2010) Structure., 18: 649-656

6. Bai, Z., Hayasaka, H (equally contribution)., Kobayashi, M., Li, W., Guo, Z., Jang, MH., Kondo, A., Choi, BI., Iwakura, Y., and Miyasaka, M. CXCL12 promotes CCR7-dependent naïve T cell trafficking to lymph nodes and Peyer’s patches. (2009) J. Immunol., 182: 1287-1295.

7. Nakasaki, T., Tanaka, T., Okudaira, S., Hirosawa, M., Umemoto, E., Otani, K., Jin, S., Bai, Z., Hayasaka, H., Fukui, Y., Aozasa, K., Fujita, N., Tsuruo, T., Osono, T., Osono, K., Aoki, J., and Miyasaka, M. Involvement of the lysophosphatidic acid-generating enzyme autotaxin in lymphocyte-endothelial cell interactions. (2008) Am. J. Pathol., 173:1566-1576.

8. Sayers, RL., Sundberg-Smith, LJ., Rojas, M., Hayasaka, H., Parsons, JT., Mack, CP., Taylor, JM., FRNK expression promotes smooth muscle cell maturation during vascular development and after vascular injury. (2008) Arterioscler Thromb. Vasc. Biol., 173:1566-1576

9. Ding, Q., Gladson, CL., Wu, H., Hayasaka, H., Olman, MA., Focal adhesion kinase (FAK)-related non-kinase inhibits myofibroblast differentiation through differential MAPK activation in a FAK-dependent manner. (2008) J. Biol. Chem., 283:26839-26849.

10. Bai, Z., Hayasaka, H., Nishiyama, M., Tanaka, T., Jang, M.H., Umemoto, E., Miyasaka, M. Heterogeneity of in vitro lymphocyte behaviours in response to different chemokines. (2008) Med. J. Osaka Univ., 51:11-20.

11. Hayasaka, H., Martin, KH., Hershey, ED., Parsons, JT. Disruption of FRNK expression by gene targeting of the intronic promoter within the focal adhesion kinase gene.
J Cell Biochem., 102:947-954, 2007.

12. Matsutani, T., Tanaka, T., Tohya, K., Otani, K., Jang, MH., Umemoto, E., Tanighchi, K., Hayasaka, H., Ueda, K., Miyasaka, M. Plasmacytoid dendritic cells employ multiple cell adhesion molecules sequentially to interact with high endothelial venule cells- Molecular basis of their trafficking to lymph nodes. (2007) Int Immunol., 19: 1031-1037.

13. Yang, BG., Tanaka, T., Jang, MH., Bai, Z., Hayasaka, H., Miyasaka, M. Binding of lymphoid chemokines to collagen IV that accumulates in the basal lamina of high endothelial venules; its implications in lymphocyte trafficking. (2007) J Immunol., 179: 4376-4382.

14. Sugahara, KN., Hirata, T., Hayasaka, H., Stern, R., Murai, T., Miyasaka, M. Tumor cells enhance their own CD44 cleavage and motility by generating hyaluronan fragments. (2006)
J Biol Chem., 281: 5861-5868.

15. Takeda, M., Ogino, S., Umemoto, R., Sakakura, M., Kajiwara, M., Sugahara, KN., Hayasaka, H., Miyasaka, M., Tarasawa, H., Shimada, I. Ligand-induced structural changes of the CD44 hyaluronan-binding domain revealed by NMR. (2006) J Biol Chem.,
281: 40089-40095.

16. Hayasaka, H., Simon, K., Hershey, ED., Masumoto, KH., Parsons, JT. FRNK, the autonomously expressed C-terminal region of focal adhesion kinase, is uniquely regulated in vascular smooth muscle: analysis of expression in transgenic mice. (2005) J Cell Biochem., 95:1248-1263.

17. Kanemitsu, N., Ebisuno, Y., Tanaka, T., Otani, K., Hayasaka, H., Kaisho, T., Akira, S., Katagiri, K., Kinashi, T., Fujita, N., Tsuruo, T., Miyasaka, M. CXCL13 is an arrest chemokine for B cells in high endothelial venules. (2005) Blood., 106:2613-2618.

18. Ishiwatari-Hayasaka, H., Maruya, M., Sreedhar, AS., Nemoto, TK., Csermely, P., Yahara, I. Interaction of neuropeptide Y and Hsp90 through a novel peptide binding region. (2003) Biochemistry., 42:12972-12980. (corresponding author)

19. Ishiwatari-Hayasaka, H., Fujimoto, T., Osawa, T., Hirama, T., Toyama-Sorimachi, N., Miyasaka, M. Requirements for signal delivery through CD44: Analysis using CD44-Fas chimeric proteins. (1999) J. Immunol., 163:1258-1264.

20. Chnaider, T., Oikarinen, J., Ishiwatari-Hayasaka, H., Yahara, I., Csermely, P. Interactions of Hsp90 with histones and related peptides. S (1999) Life Sci. 65: 2417-2426.

21. Ishiwatari-Hayasaka, H., Kawashima, H., Osawa, T., Nagata, S., Miyasaka, M. Induction of cell death by chimeric L-selectin-Fas receptors. (1997) Int Immunol. 4:627-635.

22. Ishiwatari, H., Nakanishi, K., Kondoh, G., Hayasaka, N., Li, Q., Yamashita, A., Hakura, H. Suppression of tumor growth by the 3' untranslated region of mel-18 in 3Y1 cells transformed by the E6 and E7 genes of human papillomavirus type 18. (1997) Cancer Lett. 15:117, 57-65.

23. Ishiwatari, H., Hayasaka, N., Inoue, H., Yutsudo, M., Hakura, H. Degradation of p53 only is not sufficient for the growth stimulatory effect of human papillomavirus 16 E6 oncoprotein in human embryonic fibroblasts. (1994) J. Med. Virol. 44, 243-249.

24. Inoue, T., Kyo, S., Kiyono, T., Ishibashi, M., Ishiwatari, H., Hwang, YI., Yutsudo, M., Hakura, A. Correlation between tumorigenicity and expression levels or splicing patterns of transcripts of the human papillomavirus type 16 E6 gene. (1994) Jpn J Cancer Res. 85:357-363.

25. Nakai, M., Endo, T., Hase, T., Tanaka, Y., Trumpower, BL., Ishiwatari, H., Asada, A., Bogaki, M., Matsubara, H. Acidic regions of cytochrome c1 are essential for ubiquinol-cytochrome c reductase activity in yeast cells lacking the acidic QCR6 protein. (1993) J. Biochem. 114:919-925.

26. Nakanishi, K., Hwang, YI., Ishiwatari, H., Takami, Y., Hayasaka, N., Yutsudo, M., Nojima, H., Hakura, A. Isolation of flat revertants from human papillomavirus type 18 E6E7 transformed 3Y1 cells by transfection with a rat embryo fibroblast cDNA expression library. (1993)
Cell Struct Funct. 18:457-465.

27. Nakai, M., Ishiwatari, H., Asada, A., Bogaki, M., Kawai, K., Tanaka, Y., Matsubara, H. Replacement of putative axial ligands of heme iron in yeast cytochrome c1 by site-directed mutagenesis. (1990) J. Biochem. 108:798-803.

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大阪大学
大学院医学系研究科C8
感染免疫医学講座
免疫動態学
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