阪大消化器内科のご紹介・研究実績



2015年

原著論文

  1. Akasaka T, Tsujii M, Kondo J, Hayashi Y, Ying J, Lu Y, Kato M, Yamada T, Yamamoto S, Inoue T, Tsujii Y, Maekawa A, Fujinaga T, Shiraishi E, Hiyama S, Inoue T, Shinzaki S, Watabe K, Nishida T, Iijima H, Takehara T.
    5-FU resistance abrogates the amplified cytotoxic effects induced by inhibiting checkpoint kinase 1 in p53-mutated colon cancer cells.
    Int J Oncol. 2015;46:63-70.
  2. Yoshioka T, Nishida T, Tsujii M, Kato M, Hayashi Y, Komori M, Yoshihara H, Nakamura T, Egawa S, Yoshio T, Yamada T, Yabuta T, Yamamoto K, Kinoshita K, Kawai N, Ogiyama H, Nishihara A, Michida T, Iijima H, Shintani A, Takehara T.
    Renal dysfunction is an independent risk factor for bleeding after gastric ESD.
    Endosc Int Open. 2015;3:E39-45.
  3. Sato M, Kamada Y, Takeda Y, Kida S, Ohara Y, Fujii H, Akita M, Mizutani K, Yoshida Y, Yamada M, Hougaku H, Takehara T, Miyoshi E.
    Fetuin-A negatively correlates with liver and vascular fibrosis in nonalcoholic fatty liver disease subjects.
    Liver Int. 2015;35:925-35.
  4. Oze T, Hiramatsu N, Yakushijin T, Yamada R, Harada N, Morishita N, Oshita M, Mita E, Ito T, Inui Y, Inada M, Tamura S, Yoshihara H, Imai Y, Kato M, Miyagi T, Yoshida Y, Tatsumi T, Kasahara A, Hayashi N, Takehara T.
    The real impact of telaprevir dosage on the antiviral and side effects of telaprevir, pegylated interferon and ribavirin therapy for chronic hepatitis C patients with HCV genotype 1.
    J Viral Hepat. 2015;22:254-62.
  5. Oze T, Hiramatsu N, Yakushijin T, Yamada R, Harada N, Morishita N, Yamada A, Oshita M, Kaneko A, Suzuki K, Inui Y, Tamura S, Yoshihara H, Imai Y, Miyagi T, Yoshida Y, Tatsumi T, Kasahara A, Hayashi N, Takehara T.
    The prospective randomized study on telaprevir at 1500 or 2250 mg with pegylated interferon ribavirin in Japanese patients with HCV genotype 1.
    J Gastroenterol. 2015;50:313-22.
  6. Kizu T, Yoshida Y, Furuta K, Ogura S, Egawa M, Chatani N, Hamano M, Takemura T, Ezaki H, Kamada Y, Nishida K, Nakaoka Y, Kiso S, Takehara T.
    Loss of Gab1 adaptor protein in hepatocytes aggravates experimental liver fibrosis in mice.
    Am J Physiol Gastrointest Liver Physiol. 2015;308:G613-24.
  7. Kamada Y, Sato M, Kida S, Akita M, Mizutani K, Fujii H, Sobajima T, Yoshida Y, Shinzaki S, Takamatsu S, Takehara T, Miyoshi E
    N-acetylglucosaminyltransferase V exacerbates concanavalin A-induced hepatitis in mice.
    Mol Med Rep. 2015 May;11(5):3573-84.
  8. Kato M, Nishida T, Hamasaki T, Kawai N, Yoshio T, Egawa S, Yamamoto K, Ogiyama H, Komori M, Nakahara M, Yabuta T, Nishihara A, Hayashi Y, Yamada T, Takehara T.
    Outcomes of ESD for patients with early gastric cancer and comorbid liver cirrhosis: a propensity score analysis.
    Surg Endosc. 2015;29:1560-6.
  9. Harada N, Hiramatsu N, Oze T, Tatsumi T, Hayashi N, Takehara T.
    Efficacy of pegylated interferon and ribavirin combination therapy for patients with hepatitis C virus infection after curative resection or ablation for hepatocellular carcinoma-A retrospective multicenter study.
    J Med Virol. 2015;87:1199-206.
  10. Yamada R, Hiramatsu N, Oze T, Morishita N, Harada N, Yakushijin T, Iio S, Doi Y, Yamada A, Kaneko A, Hagiwara H, Mita E, Oshita M, Itoh T, Fukui H, Hijioka T, Katayama K, Tamura S, Yoshihara H, Imai Y, Kato M, Miyagi T, Yoshida Y, Tatsumi T, Kasahara A, Hamasaki T, Hayashi N, Takehara T.
    Impact of alpha-fetoprotein on hepatocellular carcinoma development during entecavir treatment of chronic hepatitis B virus infection.
    J Gastroenterol. 2015;50:785-94.
  11. Tahata Y, Hiramatsu N, Oze T, Morishita N, Harada N, Yamada R, Yakushijin T, Mita E, Hagiwara H, Yamada Y, Ito T, Hijioka T, Inada M, Katayama K, Tamura S, Yoshihara H, Inoue A, Imai Y, Irishio K, Kato M, Hikita H, Sakamori R, Miyagi T, Yoshida Y, Tatsumi T, Hamasaki T, Hayashi N, Takehara T.
    The impact of an inosine triphosphate pyrophosphatase genotype on bilirubin increase in chronic hepatitis C patients treated with simeprevir, pegylated interferon ribavirin.
    J Gastroenterol. 2015 Jul 30.
  12. Chatani N, Kamada Y, Kizu T, Ogura S, Furuta K, Egawa M, Hamano M, Ezaki H, Kiso S, Shimono A, Ouchi N, Yoshida Y, Takehara T.
    Secreted frizzled-related protein 5 (Sfrp5) decreases hepatic stellate cell activation and liver fibrosis.
    Liver Int. 2015;35:2017-26.
  13. Hikita H, Kodama T, Tanaka S, Saito Y, Nozaki Y, Nakabori T, Shimizu S, Hayashi Y, Li W, Shigekawa M, Sakamori R, Miyagi T, Hiramatsu N, Tatsumi T, Takehara T.
    Activation of the Mitochondrial Apoptotic Pathway Produces Reactive Oxygen Species and Oxidative Damage in Hepatocytes That Contribute to Liver Tumorigenesis.
    Cancer Prev Res (Phila). 2015;8:693-701.
  14. Shiraishi E, Iijima H, Shinzaki S, Nakajima S, Inoue T, Hiyama S, Kawai S, Araki M, Yamaguchi T, Hayashi Y, Fujii H, Nishida T, Tsujii M, Takehara T.
    Vitamin K deficiency leads to exacerbation of murine dextran sulfate sodium-induced colitis.
    J Gastroenterol. 2015 Aug 28.
  15. Yamada T, Hirota M, Tsutsui S, Kato M, Takahashi T, Yasuda K, Sumiyama K, Tsujii M, Takehara T, Mori M, Doki Y, Nakajima K.
    Gastric endoscopic submucosal dissection under steady pressure automatically controlled endoscopy (SPACE); a multicenter randomized preclinical trial.
    Surg Endosc. 2015;29:2748-55.
  16. Tsujii Y, Kato M, Inoue T, Yoshii S, Nagai K, Fujinaga T, Maekawa A, Hayashi Y, Akasaka T, Shinzaki S, Watabe K, Nishida T, Iijima H, Tsujii M, Takehara T.
    Integrated diagnostic strategy for the invasion depth of early gastric cancer by conventional endoscopy and EUS.
    Gastrointest Endosc. 2015;82:452-9.
  17. Tsujii Y, Nishida T, Nishiyama O, Yamamoto K, Kawai N, Yamaguchi S, Yamada T, Yoshio T, Kitamura S, Nakamura T, Nishihara A, Ogiyama H, Nakahara M, Komori M, Kato M, Hayashi Y, Shinzaki S, Iijima H, Michida T, Tsujii M, Takehara T.
    Clinical outcomes of endoscopic submucosal dissection for superficial esophageal neoplasms: a multicenter retrospective cohort study.
    Endoscopy. 2015;47:775-83.
  18. Nishio K, Miyagi T, Tatsumi T, Mukai K, Yokoyama Y, Yoshioka T, Sakamori R, Hikita H, Kodama T, Shimizu S, Shigekawa M, Nawa T, Yoshihara H, Hiramatsu N, Yamanaka H, Seino K, Takehara T.
    Invariant natural killer T cell deficiency leads to the development of spontaneous liver inflammation dependent on γδT cells in mice.
    J Gastroenterol. 2015;50:1124-33.
  19. Kai Y, Hikita H, Tatsumi T, Nakabori T, Saito Y, Morishita N, Tanaka S, Nawa T, Oze T, Sakamori R, Yakushijin T, Hiramatsu N, Suemizu H, Takehara T.
    Emergence of hepatitis C virus NS5A L31V Y93H variant upon treatment failure of daclatasvir and asunaprevir is relatively resistant to ledipasvir and NS5B polymerase nucleotide inhibitor GS-558093 in human hepatocyte chimeric mice.
    J Gastroenterol. 2015;50:1145-51.
  20. Kamada Y, Ono M, Hyogo H, Fujii H, Sumida Y, Mori K, Tanaka S, Yamada M, Akita M, Mizutani K, Fujii H, Yamamoto A, Takamatsu S, Yoshida Y, Itoh Y, Kawada N, Chayama K, Saibara T, Takehara T, Miyoshi E.
    A novel noninvasive diagnostic method for nonalcoholic steatohepatitis using two glycobiomarkers.
    Hepatology. 2015;62:1433-43.

総説

  1. Hiramatsu N, Oze T, Takehara T.
    Suppression of hepatocellular carcinoma development in hepatitis C patients given interferon-based antiviral therapy.
    Hepatol Res. 2015;45:152-61.

症例報告

  1. Makino Y, Miyazaki M, Shigekawa M, Ezaki H, Sakamori R, Yakushijin T, Ohkawa K, Kato M, Akasaka T, Shinzaki S, Nishida T, Miyake Y, Hama N, Nagano H, Honma K, Morii E, Wakasa K, Hikita H, Tatsumi T, Iijima H, Hiramatsu N, Tsujii M, Takehara T.
    Solitary fibrous tumor of the liver from development to resection.
    Intern Med. 2015;54:765-70.
  2. Tsujii Y, Kato M, Shinzaki S, Takigawa A, Hayashi Y, Nishida T, Iijima H, Tsujii M, Takehara T.
    Polyglycolic acid sheets for repair of refractory esophageal fistula.
    Endoscopy. 2015;47 Suppl 1 UCTN:E39-40.
  3. Yoshii S, Kato M, Honma K, Fujinaga T, Tsujii Y, Maekawa A, Inoue T, Hayashi Y, Akasaka T, Shinzaki S, Nishida T, Iijima H, Tsujii M, Morii E, Takehara T.
    Esophageal adenocarcinoma with white opaque substance observed by magnifying endoscopy with narrow band imaging.
    Dig Endosc. 2015;27:392-6.
  4. Yamaguchi T, Inoue T, Nishida T, Kato M, Hayashi Y, Tsujii Y, Maekawa A, Kawai S, Fujinaga T, Araki M, Nagai K, Yoshii S, Hiyama S, Shinzaki S, Iijima H, Tsujii M, Takehara T.
    Localized gastric amyloidosis mimicking a submucosal tumor-like gastric cancer.
    Gastrointest Endosc. 2015;82:175-7.

 

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