阪大消化器内科のご紹介・研究実績



2011年

原著論文

  1. Akasaka T, Nishida T, Tsutsui S, Michida T, Yamada T, Ogiyama H, Kitamura S, Ichiba M, Komori M, Nishiyama O, Nakanishi F, Zushi S, Nishihara A, Iijima H, Tsujii M, Hayashi N.
    Short-term outcomes of endoscopic submucosal dissection (ESD) for early gastric neoplasm: multicenter survey by osaka university ESD study group.
    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 2011;23:73-7.
  2. Hikita H, Takehara T, Kodama T, Shimizu S, Shigekawa M, Hosui A, Miyagi T, Tatsumi T, Ishida H, Li W, Kanto T, Hiramatsu N, Tsujimoto Y, Hayashi N.
    Delayed-onset caspase-dependent massive hepatocyte apoptosis upon Fas activation in Bak/Bax-deficient mice.
    Hepatology 2011;54:240-51.
  3. Hiramatsu N, Inoue Y, Oze T, Kurashige N, Yakushijin T, Mochizuki K, Miyagi T, Tatsumi T, Kiso S, Kanto T, Kasahara A, Takehara T, Oshita M, Mita E, Hagiwara H, Inui Y, Katayama K, Tamura S, Yoshihara H, Imai Y, Hayashi N.
    Efficacy of pegylated interferon ribavirin combination therapy for hepatitis C patients with normal ALT levels: a matched case-control study.
    J Gastroenterol 2011;46:1335-43.
  4. Hiramatsu N, Kurosaki M, Sakamoto N, Iwasaki M, Sakamoto M, Suzuki Y, Sugauchi F, Tamori A, Kakinnuma S, Matsuura K, Izumi N.
    Pretreatment prediction of anemia progression by pegylated interferon alpha-2b ribavirin combination therapy in chronic hepatitis C infection: decision-tree analysis.
    J Gastroenterol 2011;46:1111-9.
  5. Inoue T, Iijima H, Nakajima S, Shinzaki S, Nishida T, Kanto T, Tsujii M, Wada Y, Miyoshi E, Takehara T.
    O-linked oligosaccharide alterations of IgA1 are a novel biological marker of patients with inflammatory bowel disease.
    Dig Dis Sci 2011;56:2772.
  6. Inoue Y, Hiramatsu N, Oze T, Yakushijin T, Mochizuki K, Fukuda K, Mita E, Haruna Y, Inoue A, Imai Y, Hosui A, Miyagi T, Yoshida Y, Tatsumi T, Kiso S, Kanto T, Kasahara A, Takehara T, Hayashi N.
    Amino acid substitution in the core protein has no impact on relapse in hepatitis C genotype 1 patients treated with peginterferon and ribavirin.
    J Med Virol 2011;83:419-27.
  7. Ishida H, Tatsumi T, Hosui A, Nawa T, Kodama T, Shimizu S, Hikita H, Hiramatsu N, Kanto T, Hayashi N, Takehara T.
    Alterations in microRNA expression profile in HCV-infected hepatoma cells: involvement of miR-491 in regulation of HCV replication via the PI3 kinase/Akt pathway.
    Biochemical and biophysical research communications 2011;412:92-7.
  8. Kamada Y, Kiso S, Yoshida Y, Chatani N, Kizu T, Hamano M, Tsubakio M, Takemura T, Ezaki H, Hayashi N, Takehara T.
    Estrogen deficiency worsens steatohepatitis in mice fed high-fat and high-cholesterol diet. American journal of physiology.
    Gastrointestinal and liver physiology 2011;301:G1031-43.
  9. Kanto T, Inoue M, Oze T, Miyazaki M, Sakakibara M, Kakita N, Matsubara T, Higashitani K, Hagiwara H, Iio S, Katayama K, Mita E, Kasahara A, Hiramatsu N, Takehara T, Hayashi N.
    Dynamics of regulatory T cells and plasmacytoid dendritic cells as immune markers for virological response in pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C patients.
    J Gastroenterol 2012;47:169-78.
  10. Kato M, Nishida T, Tsutsui S, Komori M, Michida T, Yamamoto K, Kawai N, Kitamura S, Zushi S, Nishihara A, Nakanishi F, Kinoshita K, Yamada T, Iijima H, Tsujii M, Hayashi N.
    Endoscopic submucosal dissection as a treatment for gastric noninvasive neoplasia: a multicenter study by Garmin.org.ua ESD Study Group.
    J Gastroenterol 2011;46:325-31.
  11. Kato M, Watabe K, Hamasaki T, Umeda M, Furubayashi A, Kinoshita K, Kishida O, Fujimoto T, Yamada A, Tsukamoto Y, Yamamoto S, Kamada Y, Yoshida Y, Kiso S, Tsutsui S, Kihara S, Hayashi N, Matsuzawa Y.
    Association of low serum adiponectin levels with erosive esophagitis in men: an analysis of 2405 subjects undergoing physical check-ups.
    J Gastroenterol 2011;46:1361-7.
  12. Kodama T, Takehara T, Hikita H, Shimizu S, Shigekawa M, Li W, Miyagi T, Hosui A, Tatsumi T, Ishida H, Kanto T, Hiramatsu N, Yin XM, Hayashi N.
    BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets.
    The Journal of biological chemistry 2011;286:13905-13.
  13. Kodama T, Takehara T, Hikita H, Shimizu S, Shigekawa M, Tsunematsu H, Li W, Miyagi T, Hosui A, Tatsumi T, Ishida H, Kanto T, Hiramatsu N, Kubota S, Takigawa M, Tomimaru Y, Tomokuni A, Nagano H, Doki Y, Mori M, Hayashi N.
    Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice.
    The Journal of clinical investigation 2011;121:3343-56.
  14. Kondo J, Endo H, Okuyama H, Ishikawa O, Iishi H, Tsujii M, Ohue M, Inoue M.
    Retaining cell-cell enables preparation and culture of spheroids composed of pure primary cancer cells from colorectal cancer.
    Proc Natl Acad Sci U S A 2011;108:6235-40.
  15. Kurosaki M, Sakamoto N, Iwasaki M, Sakamoto M, Suzuki Y, Hiramatsu N, Sugauchi F, Tamori A, Nakagawa M, Izumi N.
    Sequences in the interferon sensitivity-determining region and core region of hepatitis C virus impact pretreatment prediction of response to PEG-interferon ribavirin: data mining analysis.
    J Med Virol 2011;83:445-52.
  16. Kurosaki M, Sakamoto N, Iwasaki M, Sakamoto M, Suzuki Y, Hiramatsu N, Sugauchi F, Yatsuhashi H, Izumi N.
    Pretreatment prediction of response to peginterferon ribavirin therapy in genotype 1 chronic hepatitis C using data mining analysis.
    J Gastroenterol 2011;46:401-9.
  17. Miyagi T, Shimizu S, Tatsumi T, Nishio K, Hiramatsu N, Kanto T, Hayashi N, Takehara T.
    Differential alteration of CD56(bright) and CD56 (dim) natural killer cells in frequency, phenotype, and cytokine response in chronic hepatitis C virus infection.
    J Gastroenterol 2011;46:1020-30.
  18. Nakajima S, Iijima H, Shinzaki S, Egawa S, Inoue T, Mukai A, Hayashi Y, Kondo J, Akasaka T, Nishida T, Kanto T, Morii E, Mizushima T, Miyoshi E, Tsujii M, Hayashi N.
    Functional analysis of agalactosyl IgG in inflammatory bowel disease patients.
    Inflammatory bowel diseases 2011;17:927-36.
  19. Nishida T, Tsutsui S, Kato M, Inoue T, Yamamoto S, Hayashi Y, Akasaka T, Yamada T, Shinzaki S, Iijima H, Tsujii M, Takehara T.
    Treatment strategy for gastric non-invasive intraepithelial neoplasia diagnosed by endoscopic biopsy.
    World J Gastrointest Pathophysiol 2011;2:93-9.
  20. Oze T, Hiramatsu N, Yakushijin T, Mochizuki K, Imanaka K, Yamada A, Oshita M, Kaneko A, Hagiwara H, Mita E, Ito T, Nagase T, Inui Y, Hijioka T, Tamura S, Yoshihara H, Hayashi E, Imai Y, Kato M, Hosui A, Miyagi T, Yoshida Y, Ishida H, Tatsumi T, Kiso S, Kanto T, Kasahara A, Takehara T, Hayashi N.
    The efficacy of extended treatment with pegylated interferon ribavirin in patients with HCV genotype 1 and slow virologic response in Japan.
    J Gastroenterol 2011;46:944-52.
  21. Oze T, Hiramatsu N, Yakushijin T, Mochizuki K, Oshita M, Hagiwara H, Mita E, Ito T, Fukui H, Inui Y, Hijioka T, Inada M, Kaytayama K, Tamura S, Yoshihara H, Inoue A, Imai Y, Kato M, Miyagi T, Yoshida Y, Tatsumi T, Kiso S, Kanto T, Kasahara A, Takehara T, Hayashi N.
    Indications and limitations for aged patients with chronic hepatitis C in pegylated interferon alfa-2b ribavirin combination therapy.
    Journal of hepatology 2011;54:604-11.
  22. Oze T, Hiramatsu N, Yakushijin T, Mochizuki K, Oshita M, Hagiwara H, Mita E, Ito T, Inui Y, Fukui H, Hijioka T, Katayama K, Tamura S, Yoshihara H, Inoue A, Imai Y, Hayashi E, Kato M, Hosui A, Miyagi T, Ishida H, Yoshida Y, Tatsumi T, Kiso S, Kanto T, Kasahara A, Takehara T, Hayashi N.
    Efficacy of re-treatment with pegylated interferon ribavirin combination therapy for patients with chronic hepatitis C in Japan.
    J Gastroenterol 2011;46:1031-7.
  23. Sakakibara M, Kanto T, Hayakawa M, Kuroda S, Miyatake H, Itose I, Miyazaki M, Kakita N, Higashitani K, Matsubara T, Hiramatsu N, Kasahara A, Takehara T, Hayashi N.
    Comprehensive immunological analyses of colorectal cancer patients in the phase I/II study of quickly matured dendritic cell vaccine pulsed with carcinoembryonic antigen peptide.
    Cancer immunology, immunotherapy : CII 2011;60:1565-75.
  24. Shigekawa M, Takehara T, Kodama T, Hikita H, Shimizu S, Li W, Miyagi T, Hosui A, Tatsumi T, Ishida H, Kanto T, Hiramatsu N, Hayashi N.
    Involvement of STAT3-regulated hepatic soluble factors in attenuation of stellate cell activity and liver fibrogenesis in mice.
    Biochemical and biophysical research communications 2011;406:614-20.
  25. Shimizu S, Takehara T, Hikita H, Kodama T, Tsunematsu H, Miyagi T, Hosui A, Ishida H, Tatsumi T, Kanto T, Hiramatsu N, Fujita N, Yoshimori T, Hayashi N.
    Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma. International journal of cancer.
    Journal international du cancer 2011.
  26. Sugano K, Matsumoto Y, Itabashi T, Abe S, Sakaki N, Ashida K, Mizokami Y, Chiba T, Matsui S, Kanto T, Shimada K, Uchiyama S, Uemura N, Hiramatsu N.
    Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term low-dose aspirin therapy: results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial.
    J Gastroenterol 2011;46:724-35.
  27. Tatsumi T, Takehara T, Miyagi T, Nakazuru S, Mita E, Kanto T, Hiramatsu N, Hayashi N.
    Hepatitis C virus-specific CD8+ T cell frequencies are associated with the responses of pegylated interferon-alpha and ribavirin combination therapy in patients with chronic hepatitis C virus infection.
    Hepatol Res 2011;41:30-38.
  28. Tatsumi T, Takehara T, Miyagi T, Sugiyama T, Aketa H, Sasakawa A, Kanto T, Hiramatsu N, Hayashi N.
    alpha-Galactosylceramide activates antitumor immunity against liver tumor.
    Hepatology research 2011;41:160-169.
  29. Terabe F, Fujimoto M, Serada S, Shinzaki S, Iijima H, Tsujii M, Hayashi N, Nomura S, Kawahata H, Jang MH, Miyasaka M, Mihara M, Ohsugi Y, Kishimoto T, Naka T.
    Comparative analysis of the effects of anti-IL-6 receptor mAb and anti-TNF mAb treatment on CD4(+) T-cell responses in murine colitis.
    Inflamm Bowel Dis 2011;17:491-502.
  30. Yamamoto M, Tatsumi T, Miyagi T, Tsunematsu H, Aketa H, Hosui A, Kanto T, Hiramatsu N, Hayashi N, Takehara T.
    alpha-Fetoprotein impairs activation of natural killer cells by inhibiting the function of dendritic cells.
    Clinical and experimental immunology 2011;165:211-9.
  31. Yamamoto S, Watabe K, Tsutsui S, Kiso S, Hamasaki T, Kato M, Kamada Y, Yoshida Y, Kihara S, Umeda M, Furubayashi A, Kinoshita K, Kishida O, Fujimoto T, Yamada A, Tsukamoto Y, Hayashi N, Matsuzawa Y.
    Lower serum level of adiponectin is associated with increased risk of endoscopic erosive gastritis.
    Dig Dis Sci 2011;56:2354-60.

症例報告

  1. Abe T, Yunokizaki H, Iijima H, Tamura K, Lee ZL, Higashi D, Ebara R, Tanabe J, Tsujimoto M, Tsujii M.
    Schistosoma japonicum showing flat colon polyp appearance.
    Gastrointestinal endoscopy 2011;73:820-2.
  2. Kato M, Nakajima K, Nishida T, Yamasaki M, Tsutsui S, Ogiyama H, Yamamoto S, Yamada T, Mori M, Doki Y, Hayashi N.
    Local resection by combined laparoendoscopic surgery for duodenal gastrointestinal stromal tumor.
    Diagn Ther Endosc 2011;2011:645609.

 

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